DHT and Hair Loss
DHT and Hair Loss
This article was medically reviewed by Dr. Kuddusi Onay
Dihydrotestosterone (DHT) is an androgen hormone, a derivative of testosterone, that plays a pivotal role in the development of male characteristics. However, it also has a less favorable effect on hair follicles. DHT binds to receptors in the scalp and shrinks hair follicles, which eventually leads to hair thinning and loss.
Table of Contents
The Biological Pathways: How DHT Contributes to Hair Loss
The process starts when testosterone is converted into DHT by the enzyme 5-alpha-reductase. DHT then attaches to specific receptors in the hair follicles, particularly those located on the scalp. Over time, this leads to a phenomenon known as follicular miniaturization, where hair follicles progressively become smaller and the anagen phase of hair growth is shortened.
Identifying the Signs of DHT-Induced Hair Loss
The most common signs of DHT-induced hair loss include a receding hairline, thinning hair at the temples and crown of the head, and excessive hair shedding. Unlike other types of hair loss, the changes are typically patterned and more prevalent in certain areas of the scalp.
Genetic Factors: Who Is Most at Risk for DHT-Related Hair Loss?
Genetics play a crucial role in determining who will experience DHT-related hair loss. Those with a family history of male or female pattern baldness are at a higher risk. Genetic testing can sometimes predict the likelihood of developing severe hair loss.
DHT Blockers: Effective Treatments and How They Work
DHT blockers, such as finasteride and minoxidil, are commonly used to treat hair loss. Finasteride works by inhibiting the 5-alpha-reductase enzyme, thus reducing DHT production, while minoxidil increases blood flow to the hair follicles, promoting regrowth.
Lifestyle Changes and Remedies to Combat DHT Hair Loss
In addition to medical treatments, lifestyle changes can help manage DHT levels. These include a balanced diet rich in antioxidants and vitamins, regular exercise to reduce stress, and avoiding hairstyles that pull on the hair, potentially exacerbating hair loss.
The Future of Treatment: Emerging Research on DHT and Hair Loss
Ongoing research into DHT and hair loss is focusing on new ways to block DHT or protect hair follicles from its effects. Innovative therapies, such as stem cell treatments and advanced topical solutions, hold promise for more effective and less invasive treatment options in the future.
DHT, or Dihydrotestosterone, is a hormone derived from testosterone and is known to contribute to hair loss. It binds to receptors in hair follicles, especially in the scalp, leading to the shrinkage of these follicles which eventually causes the hair to thin and fall out.
While DHT-induced hair loss can be challenging to reverse, treatments like minoxidil and finasteride have been effective for many individuals. These treatments either increase blood flow to the follicles or decrease the production of DHT, helping to prevent further hair loss and potentially regrow some hair.
Yes, some natural remedies and lifestyle changes can help reduce DHT levels. These include foods rich in zinc, such as pumpkin seeds and spinach, which can inhibit the enzyme that converts testosterone to DHT. Herbal supplements like saw palmetto also show potential in reducing DHT levels.
DHT-related hair loss typically follows a pattern, which is often referred to as male pattern baldness or androgenetic alopecia. This includes receding hairline and thinning around the crown and temples. A dermatologist can perform tests and examine your hair loss pattern to confirm if it’s related to DHT.